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It has been more than 25 years since investigators first discussed the existence of glioma “stem” cells,7,8 but only in the last 5 years or so have scientists been able to identify such cells in tumors based on expression of specific markers or defined phenotypes and behaviors.1,3,6,9,10 This type of identification has led to the hypothesis that therapies aimed at such cells within tumors would eliminate the glioma's ability to self-renew and thus be more efficacious than current treatments that target all of the neoplasm, but
KangKBWangTTWoonCTCheahESMooreXLZhuC: Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis. Int J Radiat Oncol Biol Phys67:888–8962007
KuipersGKSlotmanBJWedekindLEStoterTRBergJSminiaP: Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition: independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration. Int J Radiat Biol83:677–6852007