Editorial: Surgery for glioblastoma multiforme

Restricted access

Malignant astrocytomas are the most common primary brain tumors, accounting for 80% of all gliomas in adults. Glioblastoma multiforme (GBM) comprises about 51% of these.3 The incidence of GBM peaks between the 7th and 9th decades of life, making it more common in the elderly (individuals 65 years of age or older), and the incidence of GBM in this age group—the fastest growing demographic in the US—appears to be increasing.7,8

Unfortunately, despite the increasing relevance of GBM in elderly patients, there has been little focus on optimization of treatment in this patient population. Several studies

Article Information

Please include this information when citing this paper: published online October 1, 2010; DOI: 10.3171/2010.8.JNS101143.

© AANS, except where prohibited by US copyright law.

Headings

References

1

Barnholtz-Sloan JSWilliams VLMaldonado JLShahani DStockwell HGChamberlain M: Patterns of care and outcomes among elderly individuals with primary malignant astrocytomas. J Neurosurg 108:6426482008

2

Brandes AAVastola FBasso UBerti FPinna GRotilio A: A prospective study on glioblastoma in the elderly. Cancer 97:6576622003

3

Central Brain Tumor Registry of the United States (CBTRUS): Primary brain tumors in the United States: statistical report 19982002http://www.cbtrus.org/reports/2005-2006/2006report.pdf [Accessed August 23 2010]

4

Chaichana KParker SOlivi AQuiñones-Hinojosa A: A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiforme. Clinical article. J Neurosurg 112:99710042010

5

Chaichana KLChaichana KKOlivi AWeingart JDBennett RBrem H: Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. Clinical article. J Neurosurg [epub ahead of print October 1 2010; DOI: 10.3171/2010.8.JNS1081]

6

Chang SMParney IFHuang WAnderson FA JrAsher ALBernstein M: Patterns of care for adults with newly diagnosed malignant glioma. JAMA 293:5575642005

7

Greig NHRies LGYancik RRapoport SI: Increasing annual incidence of primary malignant brain tumors in the elderly. J Natl Cancer Inst 82:162116241990

8

Hess KRBroglio KRBondy ML: Adult glioma incidence trends in the United States, 1977–2000. Cancer 101:229322992004

9

Keime-Guibert FChinot OTaillandier LCartalat-Carel SFrenay MKantor G: Radiotherapy for glioblastoma in the elderly. N Engl J Med 356:152715352007

10

Lamborn KRChang SMPrados MD: Prognostic factors for survival of patients with glioblastoma: recursive partitioning analysis. Neuro Oncol 6:2272352004

11

Laws ERParney IFHuang WAnderson FMorris AMAsher A: Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project. J Neurosurg 99:4674732003

12

Lowry JKSnyder JJLowry PW: Brain tumors in the elderly: recent trends in a Minnesota cohort study. Arch Neurol 55:9229281998

13

Marijnen CAvan den Berg SMvan Duinen SGVoormolen JHNoordijk EM: Radiotherapy is effective in patients with glioblastoma multiforme with a limited prognosis and in patients above 70 years of age: a retrospective single institution analysis. Radiother Oncol 75:2102162005

14

Siu LL: Clinical trials in the elderly—a concept comes of age. N Eng J Med 356:157515762007

15

Stupp RMason WPvan den Bent MJWeller MFisher BTaphoorn MJ: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:9879962005

16

Veilleux NGoffaux PBoudrias MMathieu DDaigle KFortin D: Quality of life in neurooncology—age matters. Clinical article. J Neurosurg 113:3253322010

TrendMD

Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 61 61 22
Full Text Views 85 85 9
PDF Downloads 136 136 25
EPUB Downloads 0 0 0

PubMed

Google Scholar