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The controversies surrounding the management of low-grade gliomas (LGGs) remain unresolved, particularly when it comes to the role of resection. Still, the results of the majority of careful retrospective reviews support radical resection and suggest that increased extent of resection is associated with longer-term survival. In addition, resection seems reasonable to reduce symptoms from seizures or mass effect, to provide a complete survey of the pathological content of the tumor, and to reduce the number of tumor cells available for progressive genetic change or therapeutic resistance. However, none of these rationales for resection is supported by indisputable evidence.
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ChangEFClarkAJensenRLBernsteinMGuhaACarrabbaG: Multiinstitutional validation of the University of California at San Francisco Low-Grade Glioma Prognostic Scoring System. Clinical article. J Neurosurg111:203–2102009