One of the most prolific anatomical writers of the 19th century, Hubert von Luschka made significant contributions to our knowledge of neuroanatomy. His publications and textbooks were standards for their day. However, very little is written of his life in either the English or the German literature. His name lives on eponymously in more than 20 anatomical structures, including those most relevant to the neurosurgeon, the foramina of Luschka and uncovertebral joints. In this article, the authors discuss the life and contributions of this prominent German surgeon and anatomist.