Disruption of cigarette smoking addiction after posterior cingulate damage

Case report

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The authors describe the case of a 35-year-old woman with a history of an addiction to cigarette smoking who presented with an intracerebral hemorrhage from a ruptured arteriovenous malformation. The patient reported an immediate and complete disruption of her addiction to cigarette smoking following her stroke. Structural MR imaging revealed a lesion of the posterior cingulate cortex. Neuropsychological tests showed intact cognitive functioning. This observation suggests that the posterior cingulate cortex may play a role in the addiction to cigarette smoking.

Abbreviation used in this paper: CGp = posterior cingulate cortex.

Article Information

Address correspondence to: Béchir Jarraya, M.D., Ph.D., Functional Neurosurgery Unit, Henri-Mondor Hospital, 51 Avenue Mal Delattre-Tassigny, Creteil 94010, France or CEA, DSV/I2BM, Neurospin Imaging Center, Bât 145, 91191 Gif-sur-Yvette, France. email: bechir@nmr.mgh.harvard.edu.

Please include this information when citing this paper: published online July 2, 2010; DOI: 10.3171/2010.6.JNS10346.

© AANS, except where prohibited by US copyright law.

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    Structural MR images showing damage to the right CGp. A: Axial T2 BOLD MR imaging sequence showing a parasagittal hypointense lesion involving the posterior part of right cingulum. L = left; R = right. B: Diffusion tensor imaging with fiber tracking showing the loss of fibers predominantly in the right CGp (green) as compared with the left CGp (purple).

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