Sulcal and ventricular trajectories in stereotactic surgery

Clinical article

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Object

The authors analyzed deep brain stimulation electrode trajectories on MR images to identify risks of cerebrovascular complications associated with the number of electrode insertions, traversal of a sulcus, and penetration of the ventricle.

Methods

Pre- and postoperative MR volumes were fused to determine the proximity of electrodes to a sulcus or ventricle and whether there were cortical, subcortical, or intraventricular complications. Complications were further classified as hemorrhagic or nonhemorrhagic and symptomatic or asymptomatic. The authors examined 258 electrode implantation for deep brain stimulation. There were 4 symptomatic events (1.6% incidence): 3 hemorrhagic and 1 nonhemorrhagic, all within the cortex. Asymptomatic events included cortical hemorrhage in 1 patient, nonhemorrhagic cortical changes in 6, pallidal hemorrhage in 1, thalamic infarction in 1, and intraventricular hemorrhage (IVH) in 5 patients.

Results

Proximity to a sulcus was a significant risk factor for hemorrhagic and nonhemorrhagic cortical complications (p = 0.001). There was a complication rate of 10.1% within the trajectories penetrating or adjacent to a sulcus, and a 0.7% rate with trajectories clearly positioned within the gyrus. Asymptomatic IVH was observed in 5% of ventricular penetrations. A history of hypertension was a risk factor for cortical hemorrhage (p = 0.019), but not for cortical ischemic/edematous events (p = 0.605). The number of electrode penetrations did not differ between patients with and without complications (p = 0.868), and the sequence of electrode insertions was not a risk factor in bilateral surgeries.

Conclusions

Symptomatic cortical complications occur when electrodes traverse close to a sulcus. Asymptomatic IVH occurs infrequently with ventricular penetration. Despite intraoperative efforts to avoid cortical sulci, a higher than expected incidence of electrode proximity to the sulci was identified on careful postoperative trajectory analysis. This finding emphasizes the importance of assiduously planning trajectories and reviewing cases with thorough MR analysis.

Abbreviations used in this paper: CCI = Charlson Comorbidity Index; DBS = deep brain stimulation; df = degrees of freedom; FOV = field of view; GPi = globus pallidus pars interna; ICH = intracranial hemorrhage; IVH = intraventricular hemorrhage; MER = microelectrode recording; MPRAGE = magnetization-prepared rapid acquisition gradient echo; PD = Parkinson disease; STN = subthalamic nucleus; Vim = ventral intermediate thalamic nucleus.

Article Information

Address correspondence to: W. Jeffrey Elias, M.D., Department of Neurosurgery, University of Virginia Health System, Box 800212, Charlottesville, Virginia 22908. email: wje4r@virginia.edu.

© AANS, except where prohibited by US copyright law.

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Figures

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    Coronal MR images demonstrating cortical entries. Gyral (A) and sulcal penetration (B) are shown. Sections from fused postoperative (C) and preoperative (D) MR volumes at the point of cortical penetration by DBS electrodes. Sulcal traversal could not be excluded on the right (R), and on the left (L) the electrode initially penetrates a gyrus and then a sulcus. Note occlusion of local sulci by edema and electrode artifact. Arrows indicate electrode penetration points.

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    Magnetic resonance images demonstrating ventricular penetration. Left: Coronal image showing electrode penetration (arrow) of the lateral ventricle. Right: Axial image depicting IVH.

  • View in gallery

    Magnetic resonance images showing complications of electrode implantation. Left: Hemorrhagic cortical event is demonstrated. Right: Nonhemorrhagic, cortical, hypointense T1-weighted signal is shown (arrow), which could represent ischemia, edema, or venous congestion.

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