Metachronous mature teratoma in the corpus callosum occurring 12 years after a pineal germinoma

Case report

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The authors report a metachronous germ cell tumor with different histological type occurring 12 years after resection of a pineal germinoma. Histological examination of the original tumor revealed germinoma without any other component of germ cell tumor, and the patient underwent chemotherapy followed by 24 Gy of localized irradiation. Twelve years later, follow-up MR imaging showed a round mass in the genu of the corpus callosum. Two courses of chemotherapy were administered, but the tumor size remained stable. A second operation was performed and this second tumor was completely removed. The histological diagnosis was mature teratoma. The second tumor was considered as a metachronous mature teratoma rather than a recurrence of the original germinoma. To the authors' knowledge, this combination of metachronous germ cell tumor has not previously been reported in the literature

Abbreviations used in this paper: CNS = central nervous system; GCT = germ cell tumor.

Article Information

Address correspondence to: Yuuta Kamoshima, M.D., Department of Neurosurgery, Hokkaido University Hospital, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan. email: yk156@yahoo.co.jp.

© AANS, except where prohibited by US copyright law.

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Figures

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    Left: Contrast-enhanced sagittal T1-weighted image obtained at first admission showing an enhanced mass in the pineal region and no evidence of tumor in any other area. Right: Photomicrograph of surgical specimen showing germinoma with 2-cell pattern appearance. H & E, original magnification × 200.

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    Left: Contrast-enhanced T1-weighted image obtained at second admission showing an enhancing mass localizing in the genu of the corpus callosum. Right: Photomicrograph of surgical specimen showing mature teratoma without any components of immature teratoma or germinomatous cell aggregation. H & E, original magnification × 100.

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