Optimal site in the subthalamic nucleus for deep brain stimulation

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The advent of deep brain stimulation (DBS) for individuals with the cardinal symptoms of medically intractable Parkinson disease (PD) was a major advance in the treatment of these desperate patients. Now, approximately a decade into the more routine use of this technology, reassessments of the methods and therapeutic efficacy of DBS are in order.

Although considerable worldwide experience has been gained in the application of this therapy, by contemporary standards we still lack a firm evidence base on which to definitively support the procedure. This deficit will be remedied, at least in part, by the findings of the Veterans Affairs–National

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