Glioblastoma multiforme metastasis to the axis

Case report

Restricted access

✓ Extracranial bone metastasis from glioblastoma multiforme (GBM) has rarely been reported in the literature, and most metastatic GBMs are multiple bone metastases. The authors describe the first case of a GBM with metastasis only to the axis. This 42-year-old man presented with a 2-month history of headache, nausea, vomiting, and disorientation. Magnetic resonance imaging demonstrated a right temporal tumor, which was diagnosed as a GBM based on tumor resection. The patient was treated using radiation (6000 cGy) and the intravenous administration of nimustine hydrochloride. Eighteen months thereafter, he experienced the sudden onset of neck pain. Magnetic resonance studies revealed a tumor in the axis that was diagnosed as GBM based on biopsy procedure.

Article Information

Contributor Notes

Address reprint requests to: Satoshi Utsuki, M.D., Department of Neurosurgery, Kitasato University School of Medicine, 1–15–11 Kitasato, Sagamihara, Kanagawa 228–8555, Japan. email: utsuki@med.kitasato-u.ac.jp.

© Copyright 1944-2019 American Association of Neurological Surgeons

Headings
References
  • 1

    Anzil AP: Glioblastoma multiforme with extracranial metastases in the absence of previous craniotomy. Case report. J Neurosurg 33:88941970Anzil AP: Glioblastoma multiforme with extracranial metastases in the absence of previous craniotomy. Case report. J Neurosurg 33:88–94 1970

    • Search Google Scholar
    • Export Citation
  • 2

    Beauchesne PSoler CMosnier JF: Diffuse vertebral body metastasis from a glioblastoma multiforme: a technetium-99m sestamibi single-photon emission computerized tomography study. J Neurosurg 93:8878902000Beauchesne P Soler C Mosnier JF: Diffuse vertebral body metastasis from a glioblastoma multiforme: a technetium-99m sestamibi single-photon emission computerized tomography study. J Neurosurg 93:887–890 2000

    • Search Google Scholar
    • Export Citation
  • 3

    Finsterer JBreiteneder SMueller MRWogritsch CVesely MKleinert Ret al: Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III. Oncology 55:3453481998Finsterer J Breiteneder S Mueller MR Wogritsch C Vesely M Kleinert R et al: Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III. Oncology 55:345–348 1998

    • Search Google Scholar
    • Export Citation
  • 4

    Gamis ASEgelhoff JRoloson GYoung JWoods GMNewman Ret al: Diffuse bony metastases at presentation in a child with glioblastoma multiforme. A case report. Cancer 66:1801841990Gamis AS Egelhoff J Roloson G Young J Woods GM Newman R et al: Diffuse bony metastases at presentation in a child with glioblastoma multiforme. A case report. Cancer 66:180–184 1990

    • Search Google Scholar
    • Export Citation
  • 5

    Groen RJGroenewegen HJvan Alphen HAHoogland PV: Morphology of the human internal vertebral venous plexus: a cadaver study after intravenous araldite CY 221 injection. Anat Rec 249:2852941997Groen RJ Groenewegen HJ van Alphen HA Hoogland PV: Morphology of the human internal vertebral venous plexus: a cadaver study after intravenous araldite CY 221 injection. Anat Rec 249:285–294 1997

    • Search Google Scholar
    • Export Citation
  • 6

    Hsu EKeene DVentureyra EMatzinger MAJimenez CWang HSet al: Bone marrow metastasis in astrocytic gliomata. J Neurooncol 37:2852931998Hsu E Keene D Ventureyra E Matzinger MA Jimenez C Wang HS et al: Bone marrow metastasis in astrocytic gliomata. J Neurooncol 37:285–293 1998

    • Search Google Scholar
    • Export Citation
  • 7

    Huang PAllam ATaghian AFreeman JDuffy MSuit HD: Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice. J Neurosurg 83:3083151995Huang P Allam A Taghian A Freeman J Duffy M Suit HD: Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice. J Neurosurg 83:308–315 1995

    • Search Google Scholar
    • Export Citation
  • 8

    Hübner FBraun VRichter HP: Case reports of symptomatic metastases in four patients with primary intracranial gliomas. Acta Neurochir 143:25292001Hübner F Braun V Richter HP: Case reports of symptomatic metastases in four patients with primary intracranial gliomas. Acta Neurochir 143:25–29 2001

    • Search Google Scholar
    • Export Citation
  • 9

    Kung PCLee JCBakay L: Vascular invasion by glioma cells in man: an electron microscopic study. J Neurosurg 31:3393451969Kung PC Lee JC Bakay L: Vascular invasion by glioma cells in man: an electron microscopic study. J Neurosurg 31:339–345 1969

    • Search Google Scholar
    • Export Citation
  • 10

    Longee DCFriedman HSPhillips PCBurger PCOakes WJHeffez Det al: Osteoblastic metastases from astrocytomas: a report of two cases. Med Pediatr Oncol 19:3183241991Longee DC Friedman HS Phillips PC Burger PC Oakes WJ Heffez D et al: Osteoblastic metastases from astrocytomas: a report of two cases. Med Pediatr Oncol 19:318–324 1991

    • Search Google Scholar
    • Export Citation
  • 11

    Mihara FIkeda MRothman MINumaguchi YKristt D: Vertebral body metastasis of glioblastoma multiforme with epidural mass formation. Contrast-enhanced MRI study. Clin Imaging 18:3863891994Mihara F Ikeda M Rothman MI Numaguchi Y Kristt D: Vertebral body metastasis of glioblastoma multiforme with epidural mass formation. Contrast-enhanced MRI study. Clin Imaging 18:386–389 1994

    • Search Google Scholar
    • Export Citation
  • 12

    Newton HBRosenblum MKWalker RW: Extraneural metastases of infratentorial glioblastoma multiforme to the peritoneal cavity. Cancer 69:214921531992Newton HB Rosenblum MK Walker RW: Extraneural metastases of infratentorial glioblastoma multiforme to the peritoneal cavity. Cancer 69:2149–2153 1992

    • Search Google Scholar
    • Export Citation
  • 13

    Pasquier BPasquier DN'Golet APanh MHCouderc P: Extraneural metastases of astrocytomas and glioblastomas: clinicopathological study of two cases and review of literature. Cancer 45:1121251980Pasquier B Pasquier D N'Golet A Panh MH Couderc P: Extraneural metastases of astrocytomas and glioblastomas: clinicopathological study of two cases and review of literature. Cancer 45:112–125 1980

    • Search Google Scholar
    • Export Citation
  • 14

    Pedersen PHRucklidge GJMork SJTerzis AJEngebraaten OLund-Johansen Met al: Leptomeningeal tissue: a barrier against brain tumor cell invasion. J Natl Cancer Inst 86:159315991994Pedersen PH Rucklidge GJ Mork SJ Terzis AJ Engebraaten O Lund-Johansen M et al: Leptomeningeal tissue: a barrier against brain tumor cell invasion. J Natl Cancer Inst 86:1593–1599 1994

    • Search Google Scholar
    • Export Citation
  • 15

    San Millan Ruiz DGailloud PRufenacht DADelavelle JHenry FFasel JH: The craniocervical venous system in relation to cerebral venous drainage. AJNR 23:150015082002San Millan Ruiz D Gailloud P Rufenacht DA Delavelle J Henry F Fasel JH: The craniocervical venous system in relation to cerebral venous drainage. AJNR 23:1500–1508 2002

    • Search Google Scholar
    • Export Citation
  • 16

    Smith DRHardman JMEarle KM: Metastasizing neuroectodermal tumors of the central nervous system. J Neurosurg 31:50581969Smith DR Hardman JM Earle KM: Metastasizing neuroectodermal tumors of the central nervous system. J Neurosurg 31:50–58 1969

    • Search Google Scholar
    • Export Citation
  • 17

    Vural GHagmar BWalaas L: Extracranial metastasis of glioblastoma multiforme diagnosed by fine-needle aspiration: a report of two cases and a review of the literature. Diagn Cytopathol 15:60651996Vural G Hagmar B Walaas L: Extracranial metastasis of glioblastoma multiforme diagnosed by fine-needle aspiration: a report of two cases and a review of the literature. Diagn Cytopathol 15:60–65 1996

    • Search Google Scholar
    • Export Citation
  • 18

    Wiltse LLFonseca ASAmster JDimartino PRavessoud FA: Relationship of the dura, Hofmann's ligaments, Batson's plexus, and a fibrovascular membrane lying on the posterior surface of the vertebral bodies and attaching to the deep layer of the posterior longitudinal ligament. An anatomical, radiologic, and clinical study. Spine 18:103010431993Wiltse LL Fonseca AS Amster J Dimartino P Ravessoud FA: Relationship of the dura Hofmann's ligaments Batson's plexus and a fibrovascular membrane lying on the posterior surface of the vertebral bodies and attaching to the deep layer of the posterior longitudinal ligament. An anatomical radiologic and clinical study. Spine 18:1030–1043 1993

    • Search Google Scholar
    • Export Citation
  • 19

    Yanagawa YMiyazawa TIshihara STakiguchi HShima KTerahata Set al: Pontine glioma with osteoblastic skeletal metastases in a child. Surg Neurol 46:4814841996Yanagawa Y Miyazawa T Ishihara S Takiguchi H Shima K Terahata S et al: Pontine glioma with osteoblastic skeletal metastases in a child. Surg Neurol 46:481–484 1996

    • Search Google Scholar
    • Export Citation
TrendMD
Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 197 197 74
Full Text Views 157 78 2
PDF Downloads 118 71 29
EPUB Downloads 0 0 0
PubMed
Google Scholar