Pathophysiology of trigeminal neuralgia: new evidence from a trigeminal ganglion intraoperative microneurographic recording

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✓ The origin of trigeminal neuralgia (TN) appears to be vascular compression of the trigeminal nerve at the root entry zone; however, the physiological mechanism of this disorder remains uncertain. The authors obtained intraoperative microneurographic recordings from trigeminal ganglion neurons in a patient with TN immediately before percutaneous radiofrequency-induced gangliolysis. Their findings are consistent with the idea that the pain of TN is generated, at least in part, by an abnormal discharge within the peripheral nervous system.

Article Information

Address reprint requests to: Thomas K. Baumann, Ph.D., Department of Neurological Surgery, L472, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239–3098. email: baumannt@ohsu.edu.

© AANS, except where prohibited by US copyright law.

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    Trigeminal ganglion neuron afterdischarge following gentle mechanical stimulation (mech.) of the neuralgia trigger zone. Time is given in seconds.

References

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