Pathophysiology of trigeminal neuralgia: new evidence from a trigeminal ganglion intraoperative microneurographic recording

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  • 1 Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon
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✓ The origin of trigeminal neuralgia (TN) appears to be vascular compression of the trigeminal nerve at the root entry zone; however, the physiological mechanism of this disorder remains uncertain. The authors obtained intraoperative microneurographic recordings from trigeminal ganglion neurons in a patient with TN immediately before percutaneous radiofrequency-induced gangliolysis. Their findings are consistent with the idea that the pain of TN is generated, at least in part, by an abnormal discharge within the peripheral nervous system.

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Contributor Notes

Address reprint requests to: Thomas K. Baumann, Ph.D., Department of Neurological Surgery, L472, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239–3098. email: baumannt@ohsu.edu.
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