Tremor cells in the human thalamus: differences among neurological disorders

Jason A. Brodkey Divisions of Neurosurgery and Psychology, Toronto Western Hospital; and Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada

Search for other papers by Jason A. Brodkey in
Current site
Google Scholar
PubMed
Close
 M.D.
,
Ronald R. Tasker Divisions of Neurosurgery and Psychology, Toronto Western Hospital; and Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada

Search for other papers by Ronald R. Tasker in
Current site
Google Scholar
PubMed
Close
 M.D.
,
Clement Hamani Divisions of Neurosurgery and Psychology, Toronto Western Hospital; and Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada

Search for other papers by Clement Hamani in
Current site
Google Scholar
PubMed
Close
 M.D., Ph.D.
,
Mary Pat McAndrews Divisions of Neurosurgery and Psychology, Toronto Western Hospital; and Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada

Search for other papers by Mary Pat McAndrews in
Current site
Google Scholar
PubMed
Close
 Ph.D.
,
Jonathan O. Dostrovsky Divisions of Neurosurgery and Psychology, Toronto Western Hospital; and Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada

Search for other papers by Jonathan O. Dostrovsky in
Current site
Google Scholar
PubMed
Close
 Ph.D.
, and
Andres M. Lozano Divisions of Neurosurgery and Psychology, Toronto Western Hospital; and Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada

Search for other papers by Andres M. Lozano in
Current site
Google Scholar
PubMed
Close
 M.D., Ph.D.
Restricted access

Purchase Now

USD  $45.00

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $536.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $636.00
USD  $45.00
USD  $536.00
USD  $636.00
Print or Print + Online Sign in

Object. Thalamic neurons firing at frequencies synchronous with tremor are thought to play a critical role in the generation and maintenance of tremor. The authors studied the incidence and locations of neurons with tremor-related activity (TRA) in the thalamus of patients with varied pathological conditions—including Parkinson disease (PD), essential tremor (ET), multiple sclerosis (MS), and cerebellar disorders—to determine whether known differences in the effectiveness of thalamic stereotactic procedures for these tremors could be correlated to differences in the incidence or locations of TRA cells.

Methods. Seventy-five operations were performed in 61 patients during which 686 TRA cells were recorded from 440 microelectrode trajectories in the thalamus. The locations of the TRA cells in relation to electrophysiologically defined thalamic nuclei and the commissural coordinates were compared among patient groups.

The authors found that TRA cells are present in patients with each of these disorders and that these cells populate several nuclei in the ventral lateral tier of the thalamus. There were no large differences in the locations of TRA cells among the different diagnostic classes, although there was a difference in the incidence of TRA cells in patients with PD, who had greater than 3.8 times more cells per thalamic trajectory than patients with ET and approximately five times more cells than patients with MS or cerebellar disorders.

Conclusions. There was an increased incidence of TRA in the thalamus of patients with PD. The location of thalamic TRA cells in patients with basal ganglia and other tremor disorders was similar.

  • Collapse
  • Expand
  • 1.

    Abosch A, , Hutchison WD, & Saint-Cyr JA, et al: Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease. J Neurosurg 97:11671172, 2002 Abosch A, Hutchison WD, Saint-Cyr JA, et al: Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease. J Neurosurg 97:1167–1172, 2002

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Findley LJ, & Koller WC (eds): Handbook of Tremor Disorders. New York: Marcel Dekker, 1995 Findley LJ, Koller WC (eds): Handbook of Tremor Disorders. New York: Marcel Dekker, 1995

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Hua SE, , Lenz FA, & Zirh TA, et al: Thalamic neuronal activity correlated with essential tremor. J Neurol Neurosurg Psychiatry 64:273276, 1998 Hua SE, Lenz FA, Zirh TA, et al: Thalamic neuronal activity correlated with essential tremor. J Neurol Neurosurg Psychiatry 64:273–276, 1998

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Jankovic J, , Cardoso F, & Grossman RG, et al: Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor. Neurosurgery 37:680687, 1995 Jankovic J, Cardoso F, Grossman RG, et al: Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor. Neurosurgery 37:680–687, 1995

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Kiss ZH, , Davis KD, & Tasker RR, et al: Kinaesthetic neurons in thalamus of humans with and without tremor. Exp Brain Res 150:8594, 2003 Kiss ZH, Davis KD, Tasker RR, et al: Kinaesthetic neurons in thalamus of humans with and without tremor. Exp Brain Res 150:85–94, 2003

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Koller W, , Pahwa R, & Busenbark K, et al: High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol 42:292299, 1997 Koller W, Pahwa R, Busenbark K, et al: High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol 42:292–299, 1997

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Lenz FA, , Jaeger CJ, & Seike MS, et al: Single-neuron analysis of human thalamus in patients with intention tremor and other clinical signs of cerebellar disease. J Neurophysiol 87:20842094, 2002 Lenz FA, Jaeger CJ, Seike MS, et al: Single-neuron analysis of human thalamus in patients with intention tremor and other clinical signs of cerebellar disease. J Neurophysiol 87:2084–2094, 2002

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Lenz FA, , Kwan HC, & Dostrovsky JO, et al: Single unit analysis of the human ventral thalamic nuclear group. Activity correlated with movement. Brain 113:17951821, 1990 Lenz FA, Kwan HC, Dostrovsky JO, et al: Single unit analysis of the human ventral thalamic nuclear group. Activity correlated with movement. Brain 113:1795–1821, 1990

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Lenz FA, , Kwan HC, & Martin RL, et al: Single unit analysis of the human ventral thalamic nuclear group. Tremor-related activity in functionally identified cells. Brain 117:531543, 1994 Lenz FA, Kwan HC, Martin RL, et al: Single unit analysis of the human ventral thalamic nuclear group. Tremor-related activity in functionally identified cells. Brain 117:531–543, 1994

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Lenz FA, , Normand SL, & Kwan HC, et al: Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor. Mov Disord 10:318328, 1995 Lenz FA, Normand SL, Kwan HC, et al: Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor. Mov Disord 10:318–328, 1995

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Lozano A, , Hutchison W, & Kiss Z, et al: Methods for microelectrode-guided posteroventral pallidotomy. J Neurosurg 84:194202, 1996 Lozano A, Hutchison W, Kiss Z, et al: Methods for microelectrode-guided posteroventral pallidotomy. J Neurosurg 84:194–202, 1996

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Magnin M, , Morel A, & Jeanmonod D: Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients. Neuroscience 96:549564, 2000 Magnin M, Morel A, Jeanmonod D: Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients. Neuroscience 96:549–564, 2000

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Nguyen JP, & Degos JD: Thalamic stimulation and proximal tremor. A specific target in the nucleus ventrointermedius thalami. Arch Neurol 50:498500, 1993 Nguyen JP, Degos JD: Thalamic stimulation and proximal tremor. A specific target in the nucleus ventrointermedius thalami. Arch Neurol 50:498–500, 1993

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Schaltenbrand G, & Bailey P: Introduction to Stereotaxis with an Atlas of the Human Brain. Stuttgart: Thieme, 1959 Schaltenbrand G, Bailey P: Introduction to Stereotaxis with an Atlas of the Human Brain. Stuttgart: Thieme, 1959

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Schaltenbrand G, & Wahren W: Atlas for Stereotaxy of the Human Brain. Stuttgart: Georg Thieme, 1977 Schaltenbrand G, Wahren W: Atlas for Stereotaxy of the Human Brain. Stuttgart: Georg Thieme, 1977

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Shahzadi S, , Tasker RR, & Lozano A: Thalamotomy for essential and cerebellar tremor. Stereotact Funct Neurosurg 65:1117, 1995 Shahzadi S, Tasker RR, Lozano A: Thalamotomy for essential and cerebellar tremor. Stereotact Funct Neurosurg 65:11–17, 1995

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Tasker RR: Thalamotomy. Neurosurg Clin N Am 1:841864, 1990 Tasker RR: Thalamotomy. Neurosurg Clin N Am 1:841–864, 1990

  • 18.

    Tasker RR, & Kiss ZH: The role of the thalamus in functional neurosurgery. Neurosurg Clin N Am 6:73104, 1995 Tasker RR, Kiss ZH: The role of the thalamus in functional neurosurgery. Neurosurg Clin N Am 6:73–104, 1995

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Zirh A, , Reich SG, & Dougherty PM, et al: Stereotactic thalamotomy in the treatment of essential tremor of the upper extremity: reassessment including a blinded measure of outcome. J Neurol Neurosurg Psychiatry 66:772775, 1999 Zirh A, Reich SG, Dougherty PM, et al: Stereotactic thalamotomy in the treatment of essential tremor of the upper extremity: reassessment including a blinded measure of outcome. J Neurol Neurosurg Psychiatry 66:772–775, 1999

    • PubMed
    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 1328 228 44
Full Text Views 282 38 2
PDF Downloads 237 26 3
EPUB Downloads 0 0 0