in Journal of Neurosurgery: Spine
In Brief
This study clarified whether the anterior column realignment (ACR) procedure serves well for indirect neural decompression in patients with adult spinal deformity (ASD) and pelvic incidence/lumbar lordosis mismatch. ACR worked as well as, if not better than, lateral lumbar interbody fusion for achieving indirect decompression. Segmental lordosis enhancement with ACR relied on a lever mechanism with the intact facet joints acting as the fulcrum. The ACR plays an important role in not only lumbar lordosis restoration but also stenotic spinal canal enlargement for ASD surgery.
in Journal of Neurosurgery: Spine
In Brief
The authors report their institutional experience with subsidence and reoperation using 3D-printed porous titanium (pTi) interbody cages in lateral lumbar interbody fusion (LLIF). They noted that in 55 consecutive patients with 97 treated levels with a minimum 1-year follow-up, the subsidence rate was 8.0% and the reoperation rate was 1.8%. This study corroborates previous biomechanical and case series from other institutions regarding lower subsidence after LLIF using pTi interbody cages.
in Journal of Neurosurgery: Pediatrics
In Brief
The authors aimed to provide a cognitive, somatic, and radiological landscape of 100 consecutive children with a temporal arachnoid cyst discovered incidentally or not, but rarely for cognitive disorders. Half of children (50%) had no neuropsychological disorders, especially those with incidentally discovered cysts; the other half (50%) had selective cognitive and behavior disorders that may have a long-term impact on their daily life, particularly with a right-sided and/or convex cyst. Cyst size had little effect. This study may help in better selection of patients who may benefit from surgery.
in Journal of Neurosurgery
In Brief
The results of repeat stereotactic radiosurgery (SRS) were evaluated among 229 recurrent brain metastases. At 1 year after treatment, freedom from progression was 80% and the risk of a symptomatic adverse radiation effect (ARE) was 11%, with good outcomes for metastases ≤ 2 cm and no increased risk of ARE with the use of tyrosine kinase inhibitors or immunotherapy before or after repeat SRS. The study findings will aid in patient and lesion selection for repeat SRS and interpretation of follow-up imaging after repeat SRS.
in Journal of Neurosurgery
In Brief
To clarify the pathogenesis of subarachnoid hemorrhage due to intracranial aneurysm (IA) rupture in menopause, the authors studied the role of estrogen receptors (ERa, ERβ) and NLRP3 inflammasome in a ruptured IA model in rats, human brain endothelial cells (HBECs), and human brain smooth muscle cells (HBSMCs) under estrogen-free conditions. A decrease in ERa; was associated with downregulation of Sirt1 and upregulation of the NLRP3/IL-1β/MMP-9 pathway in the rat model, HBECs, and HBSMCs. Maintaining ERa may be crucial to prevent subarachnoid hemorrhage in postmenopausal women.
in Journal of Neurosurgery: Pediatrics
In Brief
The authors conducted a retrospective prognostic analysis aimed to elucidate the best treatment strategy among embryonal tumor with multilayered rosettes (ETMR) with confirmed chromosome 19 microRNA cluster (C19MC) amplification because most previously published reports included pathologically diagnosed cases regardless of C19MC status, for which treatment analysis may have been suboptimal because of molecular heterogeneity among the tumors. Important findings indicated that a multimodal treatment approach had a great impact on the prognosis of patients with C19MC-altered ETMR.
Article Spotlight
Qualitative head-to-head comparison of headlamp and microscope for visualizing 5-ALA fluorescence during resection of glioblastoma
See Article >From the Neurosurgical Atlas
Resection of Vascular Metastasis
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March 2022 - Update on Cerebrovasospasm
Featuring presentations on selected papers published in this issue by Drs. Michael Sughrue, Saman Shabani, Laura Salgado-Lopez, and Walter Jean. Moderated by Constantinos Hadjipanayis. With William Couldwell (Editor-in-Chief) and Aaron Cohen-Gadol (Associate Editor).
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