Authors:Erica F Bisson, Jian Guan, Mohamad Bydon, Mohammed A Alvi, Anshit Goyal, Steven D Glassman, Kevin T Foley, Eric A Potts, Christopher I Shaffrey, Mark E Shaffrey, Domagoj Coric, John J Knightly, Paul Park, Michael Y Wang, Kai-Ming Fu, Jonathan R Slotkin, Anthony L Asher, Michael S Virk, Andrew Y Yew, Regis W Haid, Andrew K Chan, and Praveen V Mummaneni
Using a national registry, the authors compared the relative efficacies of decompression alone and decompression plus fusion in patients with grade I lumbar spondylolisthesis, for which ideal surgical management has not been determined despite extensive investigation. After adjusting for differences between groups, fusion remained independently associated with Oswestry Disability Index (ODI) score improvement and achieving the minimal clinically important difference in ODI score at the 24-month follow-up. The results suggest that decompression plus fusion offers superior outcomes at 24 months posttreatment compared to decompression alone for grade I lumbar spondylolisthesis.
Authors:Bing Huang, Ming Yao, QiLiang Chen, Huidan Lin, Xindan Du, Hao Huang, Xian Zhao, Huy Do, and Xiang Qian
Hemifacial spasm is a debilitating neuromuscular disorder with limited treatment options. Here the authors have described and examined the clinical efficacy of awake CT-guided radiofrequency ablation of the facial nerve to treat hemifacial spasm. Their data indicated that this approach is a precise and minimally invasive procedure that can provide effective and sustained relief for patients with hemifacial spasm, with minimal side effects.
Authors:Abigail Hellman, Teresa Maietta, Alicia Clum, Kanakaharini Byraju, Nataly Raviv, Michael D. Staudt, Erin Jeannotte, Goutam Ghoshal, Damian Shin, Paul Neubauer, Emery Williams, Tamas Heffter, Clif Burdette, Jiang Qian, Julia Nalwalk, and Julie G. Pilitsis
After demonstrating that noninvasive low intensity focused ultrasound directed at the L5 dorsal root ganglion (DRG) reduces allodynia for days in rodents, the authors advanced this treatment toward clinical use in humans by adapting the probe to treat a DRG 5 cm below the skin's surface in domestic swine. Allodynia was reduced for 5 days and pain guarding for up to 1 month after a one-time noninvasive treatment.
Authors:Abigail Hellman, Teresa Maietta, Alicia Clum, Kanakaharini Byraju, Nataly Raviv, Michael D. Staudt, Erin Jeannotte, Julia Nalwalk, Sophie Belin, Yannick Poitelon, and Julie G. Pilitsis
To develop an isolated neuropathic pain model in domestic swine, the authors created a common peroneal nerve injury that caused mechanical allodynia and leg-guarding behavior and induced demyelination of the nerve. Because of the genetic and anatomical similarities between humans and swine, this model, to the authors′ knowledge the first of its kind, will help move experimental neuropathic pain treatments developed in rodents toward clinical implementation in humans with chronic pain.
Authors:José E. Cohen, J. Moshe Gomori, Samuel Moscovici, Andrew H. Kaye, Yigal Shoshan, Sergey Spektor, and Ronen R. Leker
Despite proven efficacy in the management of selected brain aneurysms, flow-diverter stents (FDSs) are not generally used in patients with acutely ruptured aneurysms, since full aneurysm angiographic exclusion is delayed and dual-antiplatelet therapy is required. In this study, the authors found that FDSs can be safely used to manage acutely ruptured small uncoilable aneurysms in conjunction with early ventriculostomy and a strong proven antiplatelet effect. This strategy prevented aneurysm rebleeding and avoided serious procedural thromboembolic complications, with high long-term occlusion rates.