The objective of this study was to compare the epidemiology, severity, microbial causes, and management of pediatric sinusitis- and otitis media-related intracranial infections in the periods before and during the COVID-19 pandemic. At the authors' institution, there has been an approximately 3-fold increase in cases of sinusitis- and otitis media-related intracranial infections during the COVID-19 pandemic. The next steps will include expansion of this study to other pediatric centers throughout the United States and Canada.
Researchers sought to determine whether the behavior of NF2 mutant sporadic meningiomas varies based on intracranial location. They found that infratentorial tumors, as compared to their supratentorial counterparts, have more benign clinical and genomic features. Despite undergoing less extensive resection, infratentorial NF2 mutant sporadic meningiomas had similar rates of recurrence. These findings underscore the importance of achieving maximal resection, only when safe, and suggest that there may be additional biological mechanisms related to tumor location.
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The authors sought to characterize the population of patients with neural tube defects (NTDs), maternal characteristics, and referral patterns in southwestern Uganda. The majority of mothers reported prenatal folate supplementation and antenatal care, whereas an antenatal ultrasound was performed in less than one-quarter of patients. Patient mortality was associated with younger age at presentation, need for blood transfusion and oxygen supplementation, and maternal education level. This is the first study to describe the population of patients with NTDs and their mothers in southwestern Uganda.
Researchers validated an up-and-coming smartphone-based accelerometry outcome-daily steps-for patients undergoing spine surgery using the current gold-standard patient-reported outcome measures (PROMs). The key finding of the study was that pain-related PROMs correlate with daily steps and that a postoperative increase in normalized daily steps by 0.613 standard deviation from baseline may signify the minimal clinically important difference. This study adds to spine literature by advancing the use of smartphone-based objective outcomes for understanding patient improvement following surgery.
This study aimed to characterize upper-limb neurological recovery after high cervical spinal cord injury (SCI) and its association with functional independence. The recovery of the distal myotomes of the upper limb, including C7 (elbow-extension) and C8 (finger-flexion), substantially increased the degree of independence in performing functions related to tetraplegia. This information may provide important prognostic information to patients with high cervical SCI and inform design of research interventions focusing on restoration of distal myotomes.
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Featuring presentations on selected articles published in this issue by Dr. Omer Doron and Dr. Ramesh Grandhi. Co-Moderated by Dr. Adam Arthur and Stravropoula Tjoumakaris with Drs. William Couldwell (Editor-in-Chief) and Aaron Cohen-Gadol (Associate Editor).
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